The diterpenoid fungal metabolite, fujenal, has been converted into analogues of the Rabdosia diterpenoids, ent-7-hydroxy-15-oxo-6,7-secokaur-16-en-6,19-dioic acid 6,7-lactone 19-methyl ester and ent-7-acetoxy-19-hydroxy-15-oxo-6,7-secokaur-16-en-6-oic acid 6,19-lactone which possess moderate inhibitory activity against HeLa cells.
M. S. Ali, M. K. Baynham, J. R. Hanson and P. B. Hitchcock, J. Chem. Soc., Perkin Trans. 1, 1991, 2679 DOI: 10.1039/P19910002679
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