Synthesis and receptor binding affinity of 7α- and 17α-substituted 2- and 4-chloroestradiol derivatives

Abstract

Methods for the selective syntheses of 2- and 4-chloroestradiol derivatives substituted at the 17α- and 7α-positions are described. The relative binding affinities for estrogen receptors of these estrogens are also reported, and potential structure–activity relationships are put forth.