Total synthesis of kanshone A, a sesquiterpene isolated from Nardostachys chinensis (Valerianaceae)
Abstract
Kanshone A, isolated from Nardostachys chinensis(Valerianaceae), has been synthesized in 9 steps by stereoselective alkylation of the derivative methyl (5,5-ethylenedioxy-1,2-dimethylcyclohexyl)acetate and an intramolecular aldol cyclization followed by methylation and introduction of a double bond.