Structural studies on bio-active molecules. Part 17. Crystal structure of 9-(2′-phosphonomethoxyethyl)adenine (PMEA)
Abstract
The crystal structure of the antiviral agent PMEA 1 has been determined to R= 0.032 and reveals a zwitterion whose side chain emerges in-plane from the adenine ring; the conformation is compared with that of crystal structures of acyclic nucleoside analogues and AMP 2.