SCHEDULED MAINTENANCE
The reaction of quinazoline-2,4(1H,3H)-dione with N-allyl, N-benzyl and N-methyl cyclic amines in combination with phosphoryl trichloride in the presence of tripropylamine in 1,4-dioxane afforded 4-chloro-2-(cycloalkylamino)quinazolines. In the case of N-substituted pyrrolidines, 4-chloro-2-(N-substituted 4-chlorobutylamino) quinazolines were also obtained.
K. Yoshida, T. Tanaka and H. Ohtaka, J. Chem. Soc., Perkin Trans. 1, 1991, 1279 DOI: 10.1039/P19910001279
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