The angular trifluoromethyl group. Part 4. Synthesis of the 9,9,9-trifluoro analogue of the Wieland–Miescher ketone
Abstract
The 9,9,9-trifluoro analogue of the Wieland–Miescher ketone 15, intended to serve as a precursor of 19,19,9-trifluoro steroids, has been prepared from 2-trifluoromethyl-1,4-benzoquinone 1via a Diels–Alder reaction as the key step.