Issue 22, 1991

A catalytic asymmetric synthesis of α-methylene lactones by the palladium-catalysed carbonylation of prochiral alkenyl halides

Abstract

A catalytic asymmetric synthesis of the α-methylene lactones starting with the prochiral alkenyl halides 8 and 19 has been achieved for the first time, giving 9 in 57% enantiomeric excess (e.e.) and 20 in 39% e. e., respectively.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1991, 1593-1595

A catalytic asymmetric synthesis of α-methylene lactones by the palladium-catalysed carbonylation of prochiral alkenyl halides

T. Suzuki, Y. Uozumi and M. Shibasaki, J. Chem. Soc., Chem. Commun., 1991, 1593 DOI: 10.1039/C39910001593

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