An efficient stereoselective total synthesis of (–)-galactostatin (–)-1 from N-tert-butoxycarbonyi-2,3-isopropylidene L-serine methyl ester (21% overall yield) is described via thiazole intermediates serving as protected aldehydes; the parallel synthesis of the natural antipole (+)-1 starts from D-serine.
A. Dondoni, P. Merino and D. Perrone, J. Chem. Soc., Chem. Commun., 1991, 1576 DOI: 10.1039/C39910001576
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