Treatment of N-allylamides 1a–c and lactams 1d–f with molecular oxygen in the presence of [PdCl2(MeCN)2]–CuCl catalyst in anhydrous 1,2-dichloroethane containing hexamethylphosphoric triamide gives the corresponding aldehydes 2 regioselectively, while methyl ketones 3 become the major products in the presence of water.
T. Hosokawa, S. Aoki, M. Takano, T. Nakahira, Y. Yoshida and S. Murahashi, J. Chem. Soc., Chem. Commun., 1991, 1559 DOI: 10.1039/C39910001559
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