A practical and efficient method for the construction of the biphenyl framework; nucleophilic aromatic substitution on 2-methoxybenzoates with aryl grignard reagents
Abstract
Treatment of 2-methoxybenzoic esters derived from 2, 6-dialkylphenols with aryl Grignard reagents afforded 1,1′-biphenyl-2-carboxylates in excellent yields.