Design and synthesis of cobalt(III) nitrogen mustard complexes as hypoxia selective cytotoxins. The X-ray crystal structure of bis(3-chloropentane-2,4-dionato)(RS-N,N′-bis(2-chloroethyl)ethylenediamine)cobalt(III) perchlorate, [Co(Clacac)2(bce)]ClO4
Abstract
The design, synthesis and biological evaluation of [Co(Meacac)2(dce)]+, a cobalt(III) nitrogen mustard complex that is effective as a hypoxia selective cytotoxin for potential anti-cancer use, is reported.