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Issue 17, 1991
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Synthesis and characterization of 2H-, 3H- and 4H-azepine: the first observation of the thermal distribution equilibrium of azepines

Abstract

Demethoxycarbonylation of methyl 2,5,-di-tert-butyl-1H-azepine-1-carboxylate using 1,8-diazabicyclo[5.4.0]undec-7-ene gives exclusively two isomers of 3H-azepine derivatives, while methyl 3,6-di-tert-butyl-1H-azepine-1-carboxylate gives a mixture of 2H-, 3H- and 4H-azepine derivatives under the same conditions because of a 1,5-hydrogen shift in the resulting triene system.

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Article type: Paper
DOI: 10.1039/C39910001154
J. Chem. Soc., Chem. Commun., 1991, 1154-1156

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    Synthesis and characterization of 2H-, 3H- and 4H-azepine: the first observation of the thermal distribution equilibrium of azepines

    K. Satake, R. Okuda, M. Hashimoto, Y. Fujiwara, I. Watadani, H. Okamoto, M. Kimura and S. Morosawa, J. Chem. Soc., Chem. Commun., 1991, 1154
    DOI: 10.1039/C39910001154

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