A novel peptide, konbamide 1, with calmodulin antagonistic activity has been isolated from the Okinawan marine sponge Theonella sp. and the structure elucidated to be a unique hexapeptide with an ureido bond on the basis of spectroscopic data, including two-dimensional NMR techniques and FAB MS–MS analysis (FAB = fast atom bombardment).
J. Kobayashi, M. Sato, T. Murayama, M. Ishibashi, M. R. Wälchi, M. Kanai, J. Shoji and Y. Ohizumi, J. Chem. Soc., Chem. Commun., 1991, 1050 DOI: 10.1039/C39910001050
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