In contrast to high chemical stability (t1/2 55.4 h at 36.4 °C), with porcine liver Carboxyesterase the title compound 1 spontaneously decomposes first to the monoester 2 then to methylphosphonate, both reactions proceeding via the 4-hydroxybenzyl intermediates 3 and 4.
S. Freeman, W. J. Irwin, A. G. Mitchell, D. Nicholls and W. Thomson, J. Chem. Soc., Chem. Commun., 1991, 875 DOI: 10.1039/C39910000875
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