In 0.1 mol dm–3 sodium carbonate buffer at pH 11.5 the pseudo first-order rate constants for the hydrolysis of the diastereoisomers of the title compound to give Ibuprofen {2-[4-(2-methylpropyl)phenyl]propanoic acid} and β-cyclodextrin are 2.97 × 10–5 s–1 and 3.16 × 10–4 s–1, with the diastereoisomer derived from (R)-Ibuprofen being the most susceptible to hydrolysis.
J. H. Coates, C. J. Easton, S. J. van Eyk, B. L. May, P. Singh and S. F. Lincoln, J. Chem. Soc., Chem. Commun., 1991, 759 DOI: 10.1039/C39910000759
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