Investigations of aristeromycin biosynthesis: evidence for the intermediacy of a 2α,3α-dihydroxy-4β-(hydroxymethyl)cyclopentane-1β-amine
Abstract
Administration of doubly-labelled forms of D-glucose to the fermentation broth of Streptomyces citricolor followed by isotopic trapping has provided evidence for the intermediacy of a 2α,3α-dihydroxy-4β-(hydroxymethyl)cyclopentane-1β-amine 7 or 8 in the biosynthesis of the nucleoside antibiotic aristeromycin 1.