Kinetics of phase-transfer etherification reactions of p-chloronitrobenzene by alkoxides

Abstract

The substitution reaction of chloride by alkoxide anions in p-chloronitrobenzene in a Phase-transfer catalytic system has been studied and successfully performed in high yield and without the occurrence of side reactions. The effect of several parameters has been experimentally, investigated. In particular, the poisoning effect of the chloride anion produced throughout the reaction is studied and a practical answer to successfully overcome this problem and increase yields is presented. A kinetic model based on the collected data is proposed.