A highly stereoselective synthesis of (±)-fragranol 1 has been accomplished from the readily available homoallylic alcohol 3 in 11 steps in 10.5% overall yield utilizing an intramolecular ester enolate alkylation as the key step.
D. Kim, Y. K. Lee, Y. M. Jang, I. O. Kim and S. W. Park, J. Chem. Soc., Perkin Trans. 1, 1990, 3221 DOI: 10.1039/P19900003221
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