Change of regioselectivity in the reaction of tin enolates and α-bromo ketones; synthesis of 1,4-diketones under non-radical conditions

Abstract

The reaction of tin enolates with α-halogeno ketones, strikingly effected by the addition of phosphine oxides to the reaction mixture, produced 1,4-diketones under mild conditions; the addition was shown to proceed in a non-radical manner.