3,4-Disubstituted tetrahydrofurans (1)–(4) and (7) of high optical purities have been prepared by enantioselective enzymic hydrolysis of their acetates (±)-(1a)–(4a) and (7a) using a lipase from Pseudomonas sp. (SAM-II).
R. Seemayer and M. P. Schneider, J. Chem. Soc., Perkin Trans. 1, 1990, 2359 DOI: 10.1039/P19900002359
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