The synthesis of novel prostaglandin analogues via cycloaddition reactions
Abstract
The total synthesis of the cyclobutane prostaglandin analogues (4) and (5), and their subsequent conversion to the γ-lactones (6) and (7), γ-lactam (8) and cyclopentanone (9) is described. The cornerstone of the synthetic strategy is the intermolecular [2 + 2] cycloaddition of dichloroketene to a suitably functionalised enol ether.