Issue 5, 1990

Synthetic investigation on isothiazolo-[5,4-b]- and -[4,5-c]-pyridines

Abstract

Different approaches to the title ring systems were examined, based on the cleavage of the N–O bond in the isoxazolopyridine-4-thiols (3) and (4) which afforded the hydroxy derivatives (6) and (7), respectively, in moderate to good yields. 3-Methylisothiazolo-[5,4-b]- and -[4,5-c]-pyridine (11) and (18), as well as several functionalized derivatives, were easily obtained from these key intermediates through the corresponding 4,6-dichloroisothiazolopyridines (10) and (17).

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1990, 1477-1480

Synthetic investigation on isothiazolo-[5,4-b]- and -[4,5-c]-pyridines

S. Chimichi, R. Nesi, F. Ponticelli and P. Tedeschi, J. Chem. Soc., Perkin Trans. 1, 1990, 1477 DOI: 10.1039/P19900001477

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