Copper(II) complexes with anti-inflammatory drugs as ligands. Molecular and crystal structures of bis(dimethyl sulphoxide)tetrakis(6-methoxy-α-methyl-2-naphthaleneacetato)dicopper(II) and bis(dimethyl sulphoxide)tetrakis[1-methyl-5-(p-toluoyl)-1H-pyrrole-2-acetato]dicopper(II)

Abstract

The copper complexes of tolmetin [1-methyl-5-(p-toluoyl)-1H-pyrrole-2-acetic acid (HL¹)], ibuprofen [α-methyl-4-(isopropylmethyl)benzeneacetic acid (HL²)], and naproxen [6-methoxy-α-methyl-2-naphthaleneacetic acid (HL³)], common anti-inflammatory drugs were prepared and characterized. The available evidence supports a dimeric structure for the dimethyl sulphoxide (dmso) adducts and monomeric for the pyridine analogues. The e.s.r. spectra of the powdered solids are consistent with spin S= 1 and g values for dimers, g_∥= 2.38 and g_⊥= 2.07. The crystal structures of [Cu₂L¹₄(dmso)₂] and [Cu₂L³₄(dmso)₂] have been determined and refined by least-squares methods using three-dimensional Mo-K_α data. The complex [Cu₂L¹₄(dmso)₂] crystallizes in space group P in a cell of dimensions a= 9.008(2), b= 12.902(4), c= 14.446(4)Å, α= 97.98(2), β= 81.52(2), and γ= 108.94(2)°. The Cu ⋯ Cu separation was 2.662(1)Å. The complex [Cu₂L³₄(dmso)₂] crystallizes in space group P2₁ in a cell of dimensions a= 17.166(2), b= 10.518(2), c= 18.184(3)Å, and β= 118.69(1)°. The Cu ⋯ Cu separation was 2.629 (1)Å.