A rapid method for the synthesis of water-soluble platinum(II) amine and pyridine complexes

Abstract

Seventeen cis-[Pt(am)₂(ONO₂)₂] complexes (am = methylamine, cycloalkylamines, substituted pyridines, aniline, or benzylamine; 2am = 2,2′-bipyridyl) were synthesized by reaction of cis-[Pt(am)₂l₂] with silver nitrate in acetone. The reaction was rapid (5–20 min at room temperature) with a yield of about 85%. The complexes appear to be stable in acetone with respect to isomerization. Thus, after 1 h at 25 °C acetone solutions of cis-[Pt(am)₂X₂](am = cyclohexylamine or 4-methylpyridine; X = I or ONO₂) showed no isomerization judging by ¹H n.m.r. spectroscopy of these compounds and their corresponding trans isomers.