The ketone 3 has been resolved using various enzyme-catalysed reactions and the enantiomer (+)-3 was transformed into the benzoate 8 while (–)-3 was converted into the esters 10 and 11; compounds 8 and 10 are complementary sections of leukotriene B4 while compounds 8 and 11 are late-stage synthons for leukotriene B3.
I. C. Cotterill, G. Dorman, K. Faber, R. Jaouhari, S. M. Roberts, F. Scheinmann, J. Spreitz, A. G. Sutherland, J. A. Winders and B. J. Wakefield, J. Chem. Soc., Chem. Commun., 1990, 1661 DOI: 10.1039/C39900001661
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