Issue 20, 1990

Conversion of N-terminal cysteine to thiazolidine carboxylic acid during hydrogen fluoride deparotection of peptides containing Nπ-bom protected histidine

Abstract

Formaldehyde released during hydrogen fluoride deprotection of peptides containing a histidine residue protected by the Nπ-benzyloxymethyl (Bom) group induces cyclisation of N-terminal cysteine to thiazolidine carboxylic acid (Thz).

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1990, 1402-1403

Conversion of N-terminal cysteine to thiazolidine carboxylic acid during hydrogen fluoride deparotection of peptides containing Nπ-bom protected histidine

J. Gesquièe, E. Diesis and A. Tartar, J. Chem. Soc., Chem. Commun., 1990, 1402 DOI: 10.1039/C39900001402

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