SCHEDULED MAINTENANCE
The conjugate addition of the Fleming silylcuprate reagent to methyl crotonate and enolate trapping by methyl 4-methoxyphenyliminoacetate produced a high yield of (1′S*,3R*,4S)-3-[1-(dimethylphenylsilyl)ethyl]-4-methoxycarbonyl-1-(4-methoxyphenyl)azetidin-2-one as a (±)-thienamycin building block.
C. Palomo, J. M. Aizpurua and R. Urchegui, J. Chem. Soc., Chem. Commun., 1990, 1390 DOI: 10.1039/C39900001390
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