The first non-enzymatic reduction of acetaldehyde and analogues by an NADH model compound
Abstract
An acid-stable NADH model compound, 9,10-dihydro-10-methylacridine (AcrH2) efficiently reduces acetaldehyde and analogues in the presence of HClO4 in acetonitrile to yield 10-methylacridinium ion and the corresponding alcohols; rates of the acid-catalysed reduction of various aliphatic aldehydes and ketones by AcrH2, which have small primary kinetic isotope effects (kH/kD < 2.0), are well correlated with those of the acid-catalysed electron transfer from the excited state of [Ru(bpy)3]2+(bpy 2,2′-bipyridine) to the same substrates.