Reduction of the α-oxo amide derived from phenylglyoxylic acid, containing (5S)-5-benzyl-2,2,3-trimethylimidazolidin-4-one as a chiral auxiliary, with NaBH4 or via fluoride ion-induced hydrosilylation with HSiMe2Ph was found to proceed with 90–100% diastereoselectivity.
I. Solodin, Y. Goldberg, G. Zelčāns and E. Lukevics, J. Chem. Soc., Chem. Commun., 1990, 1321 DOI: 10.1039/C39900001321
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