Biosynthesis of vitamin B12: formation of pyrrocorphins by peripheral C-methylation of precorrin-3 octamethyl ester
Abstract
The ester of precorrin-3 (4) is converted by metallation tautomerisation followed by C-methylation and tautomerisation-demetallation into a family of isomers from which are isolated trans-, and cis-Cpyrrocorphins for biosynthetic studies on vitamin B12.