Issue 13, 1990

Synthesis of 6(S)-amino-7-cyclohexyl-4,4-difluoro-3(R),5(R)-dihydroxy-2-methyiheptane, a novel dipeptide mimic

Abstract

The incorporation of the novel dipeptide mimic (1), synthesized via Boc-L-cyclohexylalaninol (Boc = t-butoxycarbonyl), into a dipeptide sequence has led to a very potent renin inhibitor.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1990, 904-905

Synthesis of 6(S)-amino-7-cyclohexyl-4,4-difluoro-3(R),5(R)-dihydroxy-2-methyiheptane, a novel dipeptide mimic

H. L. Sham, C. A. Rempel, H. Stein and J. Cohen, J. Chem. Soc., Chem. Commun., 1990, 904 DOI: 10.1039/C39900000904

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