Preparation of optically active 6′-fluorocarbocyclic nucleosides utilising an enantiospecific enzyme-catalysed Baeyer–Villiger type oxidation
Abstract
Kinetic resolution of the racemic ketone (±)-(1) was achieved using Acinetobacter NCIB 9871: the optically active norbornanone was converted into the carbocyclic nucleosides (5) and (7).