Issue 7, 1990
From the journal:

Journal of the Chemical Society, Chemical Communications

Synthesis of isotopically chiral [13C]penciclovir (BRL 39123) and its use to determine the absolute configuration of penciclovir triphosphate formed in herpes virus infected cells

Richard L. Jarvest,   Roger D. Barnes,   David L. Earnshaw,   Kevin J. O'Toole,   John T. Sime  and  R. Anthony Vere Hodge  

Abstract

Isotopically chiral [13C]penciclovir (BRL 39123) has been synthesised via a stereospecific hydrolysis catalysed by the lipase from Candida cylindraceae and has been used to determine, by 13C NMR, that the triphosphate of penciclovir formed in herpes simplex type 1 infected cells has (S) stereochemistry with an enantiomeric purity of > 95%.

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Article information

DOI
https://doi.org/10.1039/C39900000555
Article type
Paper

J. Chem. Soc., Chem. Commun., 1990, 555-556

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Synthesis of isotopically chiral [13C]penciclovir (BRL 39123) and its use to determine the absolute configuration of penciclovir triphosphate formed in herpes virus infected cells

R. L. Jarvest, R. D. Barnes, D. L. Earnshaw, K. J. O'Toole, J. T. Sime and R. A. V. Hodge, J. Chem. Soc., Chem. Commun., 1990, 555 DOI: 10.1039/C39900000555

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