Issue 7, 1990

A new approach for the synthesis of tyrosine sulphate containing peptides: use of the p-(methylsulphinyl)benzyl group as a key protecting group of serine

Abstract

A convenient method for the synthesis of tyrosine sulphate [Tyr(SO3H)] containing peptides, using Fmoc–solid-phase strategy (Fmoc = fluoren-9-ylmethoxycarbonyl) for peptide-chain construction and O-p-(methylsulphinyl)benzyl serine for the selective sulphation of tyrosine, has been developed and cholecystokinin (CCK)-12 synthesized as a model peptide.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1990, 523-524

A new approach for the synthesis of tyrosine sulphate containing peptides: use of the p-(methylsulphinyl)benzyl group as a key protecting group of serine

S. Futaki, T. Taike, T. Akita and K. Kitagawa, J. Chem. Soc., Chem. Commun., 1990, 523 DOI: 10.1039/C39900000523

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