Issue 2, 1990

The demonstration of selective peptide bond formation in clear aqueous solutions

Abstract

The distribution of dipeptides upon treatment of equimolar amounts of glutamic acid, leucine, and C6H11N[double bond, length half m-dash]C[double bond, length half m-dash]N(CH2)3+NMe3OSO2C6H4Me-p, in clear aqueous solution followed by N, C-protection, was found to be: Bz-Glu(γ-OMe)-Leu-OMe (72%), Bz-Glu(α-OMe)-Glu-di-OMe (15%), and Bz-Leu-Leu-OMe (8%); Bz-Leu-Glu-di-OMe, Bz-Glu(α-OMe)-Leu-OMe, and Bz-Glu(γ-OMe)Glu-di-OMe could not be detected (Bz = PhCO).

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1990, 142-143

The demonstration of selective peptide bond formation in clear aqueous solutions

D. Ranganathan and G. P. Singh, J. Chem. Soc., Chem. Commun., 1990, 142 DOI: 10.1039/C39900000142

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