Determination of diphenhydramine hydrochloride by flow injection with Bromophenol Blue and turbidimetric measurement

Abstract

The study of a number of diphenhydramine-dye systems was carried out in order to determine the most suitable precipitate for the turbidimetric determination of diphenhydramine using flow injection (Fl). The reagent selected was Bromophenol Blue. The chemical and Fl variables were optimised. The calibration graph was linear over the concentration range 50–230 p.p.m. of diphenhydramine hydrochloride. A number of interfering substances were also investigated.