Issue 6, 1989

Crystal structure of tolazoline hydrochloride (priscoline), an α-adrenergic antagonist

Abstract

The crystal and molecular structure of tolazoline hydrochloride (priscoline), an α-adrenergic antagonist which is clinically used as a vasodilating drug, has been studied by X-ray diffraction methods. The results show that the imidazole group is involved in a protonation process, the positive charge being dispersed over both nitrogen atoms of the imidazole ring, and the molecule adopts a biplanar conformation with an angle of 89.3(2)° between the phenyl and imidazole rings—an orientation which seems to be relevant for their interaction at the receptor site. Critical sites for the interaction of the adrenergic dihydroimidazoles with the α-receptors are discussed.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 2, 1989, 599-601

Crystal structure of tolazoline hydrochloride (priscoline), an α-adrenergic antagonist

S. Ghose and J. K. Dattagupta, J. Chem. Soc., Perkin Trans. 2, 1989, 599 DOI: 10.1039/P29890000599

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements