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Issue 12, 1989
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Preparation of 1, 1-disubstituted hydrazines and their 2-acyl derivatives

Abstract

1-(1-Hydroxymethyl)benzotriazole converts 1-acyl- and 1-acyl-2-aryl-hydrazines into their 2-mono-N- or 2,2-bis-N-[(benzotriazol-1-yl)methyl] derivatives, respectively, in high yields. These adducts react readily with NaBH4, Grignard reagents, and lithium acetylides to give the corresponding 2 substituted, or 2,2-disubstituted, 1-acylhydrazines in high yields. The N-(t-butoxycarbonyl)hydrazines are readily hydrolysed offering a convenient synthetic route to 1,1-dialkyl- and 1-alkyl-1-aryl-hydrazines.

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Article type: Paper
DOI: 10.1039/P19890002297
J. Chem. Soc., Perkin Trans. 1, 1989, 2297-2303

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    Preparation of 1, 1-disubstituted hydrazines and their 2-acyl derivatives

    A. R. Katritzky and M. S. C. Rao, J. Chem. Soc., Perkin Trans. 1, 1989, 2297
    DOI: 10.1039/P19890002297

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