Syntheses of C- and N-functionalised derivatives of 1,5,9-triazacyclododecane
Abstract
The synthesis of a series of di- and tri-N-substituted triazacyclododecane ligands has been effected through the intermediary of monotosylamide derivatives. A C-functionalised aminobenzyl [12]-N3 tris(carboxymethyl) derivative has been prepared permitting subsequent linkage to a protein.