Preparation and isomerisation of some steroidal hydroxy epoxides
Abstract
The preparation of 4β,5-epoxy-3β-methoxy-5β-cholestan-6β-ol (3), its 4α,5α-isomer (5), and their 3-epimers, (16) and (21) respectively, are described. It is shown that the vicinal hydroxy epoxide (21) and the isomeric compound 5,6β-epoxy-3α-methoxy-5β-cholestan-4α-ol (22) are interconvertible by a process of epoxide migration.