Synthesis of 4- and 5-regioselectively deuteriated geranyl diphosphates
Abstract
[4-2H]- and [5-2H2]-Geranyl diphosphates have been synthesized from 6-methylhept-5-en-2-one and 3-methylbut-2-enoic acid with the regioselective synthesis of 6-methylhepta-2,5-dien-2-yl acetate and the acetoacetic ester synthesis of 6-methyl[4-2H2]hept-5-en-2-one as the key steps, respectively.