Absolute configurations of the liverwort sesquiterpenoids, (–)-chiloscyphone and (+)-chiloscypholone: total synthesis of optically active compounds

Abstract

The absolute configurations of (–)-chiloscyphone and (+)-chiloscypholone isolated from the liverworts Chiloscyphus polyanthus and C. pallescens have been determined by the total synthesis of the optically active compounds. The key intermediate alcohol has been resolved by the use of (1S)-(–)-camphanic chloride.