Unambiguous synthesis of 3-aryloxymethylmorpholine hydrochlorides without ring enlargement side reactions
Abstract
The unambiguous synthesis of 3-naphthyloxymethylmorpholine hydrochloride appetite suppressants is reported. Chemoselective reduction of 4-benzyl-5-oxomorpholine-3-carboxylic acid and its derivatives is described under various metal hydride reducing conditions.