Alkynylation of S-alkylthioamidium salts of thiolactams with lithium acetylides followed by reduction with LiAIH4 provided α-alkynylazacycloalkanes, which on reduction, or hydroboration followed by oxidation, gave α-substituted pyrrolidine and piperidine alkaloids.
H. Takahata, K. Takahashi, E. Wang and T. Yamazaki, J. Chem. Soc., Perkin Trans. 1, 1989, 1211 DOI: 10.1039/P19890001211
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