Addition of O-alkyl O′-trimethylsilyl ketene acetals to arynes generated from several aryl halides with NaNH2
Abstract
A number of alkyl-substituted aromatic carboxylic acids, in which an alkyl substituent and the carboxy group are situated ortho to each other, could be synthesized by treatment of O-alkyl O′-trimethylsilyl ketene acetals with several aryl halides in the presence of an excess of NaNH2 at room temperature followed by hydrolysis with aqueous hydrochloric acid.