The only protection required in a five-step synthesis of the α-L-fucosidase inhibitor, deoxyfuconojirimycin [1,5-dideoxy-1,5-imino-L-fucitol] from D-lyxonolactone, a readily available chiral pool material, is a single isopropylidene group.
G. W. J. Fleet, S. Petursson, A. L. Campbell, R. A. Mueller, J. R. Behling, K. A. Babiak, J. S. Ng and M. G. Scarosc, J. Chem. Soc., Perkin Trans. 1, 1989, 665 DOI: 10.1039/P19890000665
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