Issue 1, 1989

The unusual co-ordination ability of vasopressin-like peptides; potentiometric and spectroscopic studies of some copper(II) and nickel(II) complexes

Abstract

The results are reported of a potentiometric and spectroscopic study of the H+, Cu2+, and Ni2+ complexes of [Arg8]vasopressin, [Arg8]vasotocin and some synthetic analogues containing the D-valyl residue in place of the glutamine residue at 25 °C and an ionic strength 0.10 mol dm–3(KNO3). The complexes of vasopressin and vasotocin with CuII are the most stable Cu-peptide complexes with 4N co-ordination yet reported. This results from the favourable conformation of the binding site within the ring formed by the disulphide bridge of the peptide. The high stability is lost when a non-co-ordinating residue in the ring (Gln) is replaced by a residue of opposite chirality (D–Val) as a result of steric hindrance between the α-carbon atom of the Val side chain and the neighbouring carbonyl oxygen.

Article information

Article type
Paper

J. Chem. Soc., Dalton Trans., 1989, 173-177

The unusual co-ordination ability of vasopressin-like peptides; potentiometric and spectroscopic studies of some copper(II) and nickel(II) complexes

H. Kozlowski, B. Radomska, G. Kupryszewski, B. Lammek, C. Livera, L. D. Pettit and S. Pyburn, J. Chem. Soc., Dalton Trans., 1989, 173 DOI: 10.1039/DT9890000173

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements