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Issue 1, 1989
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The unusual co-ordination ability of vasopressin-like peptides; potentiometric and spectroscopic studies of some copper(II) and nickel(II) complexes

Abstract

The results are reported of a potentiometric and spectroscopic study of the H+, Cu2+, and Ni2+ complexes of [Arg8]vasopressin, [Arg8]vasotocin and some synthetic analogues containing the D-valyl residue in place of the glutamine residue at 25 °C and an ionic strength 0.10 mol dm–3(KNO3). The complexes of vasopressin and vasotocin with CuII are the most stable Cu-peptide complexes with 4N co-ordination yet reported. This results from the favourable conformation of the binding site within the ring formed by the disulphide bridge of the peptide. The high stability is lost when a non-co-ordinating residue in the ring (Gln) is replaced by a residue of opposite chirality (D–Val) as a result of steric hindrance between the α-carbon atom of the Val side chain and the neighbouring carbonyl oxygen.

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Article type: Paper
DOI: 10.1039/DT9890000173
J. Chem. Soc., Dalton Trans., 1989, 173-177

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    The unusual co-ordination ability of vasopressin-like peptides; potentiometric and spectroscopic studies of some copper(II) and nickel(II) complexes

    H. Kozlowski, B. Radomska, G. Kupryszewski, B. Lammek, C. Livera, L. D. Pettit and S. Pyburn, J. Chem. Soc., Dalton Trans., 1989, 173
    DOI: 10.1039/DT9890000173

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