The new medium membered heterocycles (2c–i), additionally strained due to internal substituents, could be obtained after optimization of a simple one-step cyclisation reaction; the barrier of the restricted rotations of the phenyl ring in (2h) and of the t-butyl group in (2i) were measured; the X-ray, NMR, and CD data of the stable enantiomers of (2c–i) are compared with those of the less strained parent skeleton (2a).
F. Vögtle, A. Ostrowicki, P. Knops, P. Fischer, H. Reuter and M. Jansen, J. Chem. Soc., Chem. Commun., 1989, 1757 DOI: 10.1039/C39890001757
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