The alkaloids salutaridine and berbamunine are formed by intramolecular C–C and intermolecular C–O coupling, respectively, catalysed by cytochrome P-450 linked NADPH and O2 dependent microsomal bound plant specific enzymes.
M. H. Zenk, R. Gerardy and R. Stadler, J. Chem. Soc., Chem. Commun., 1989, 1725 DOI: 10.1039/C39890001725
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