Cyclic sulphamidite analogues of penicillanic acid
Abstract
Diastereoisomeric analogues of penicillanic acid have been synthesised in which the β-lactam ring is replaced with the 2-oxo-1,2,3-oxathiazolidine (cyclic sulphamidite) ring; ring fusion greatly increases the chemical reactivity of the 2-oxo-1,2,3-oxathiazolidine ring to nucleophilic attack.